Auclair Lab
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Publications(supervised trainees; corresponding author*)

2022

Kaabel, S. Arciszewski, J., Borchers, T. H., Therien, J. P. D., Friščić*, T., Auclair*, K., Solid-State Enzymatic Hydrolysis of Mixed PET/Cotton Textiles. ChemSusChem. 2022, e202201613.

Nzediegwu, E., Perez-Venegas, M., Auclair*, K., Dumont*, M.-J. Semisynthetic production of hydroxymethylfurfural and furfural: The benefits of an integrated approach. J. Environ. Chem. Eng. 2022, https://doi.org/10.1016/j.jece.2022.108515

Al Amin Leamon, A. K. M., Perez-Venegas, M., Orsat, V., Auclair*, K., Dumont* M.-J. Semisynthetic transformation of banana peel to enhance the conversion of sugars to 5-hydroxymethylfurfural. Biores. Tech. 2022, 362, 127782.

Arciszewski, J., Auclair*, K. Mechanoenzymatic reactions involving polymeric substrates or products. ChemSusChem, 2022, 15, e202102084.

Duncan, D., Auclair*, K. Itaconate: an antimicrobial metabolite of macrophages. Can. J. Chem. 2022, 100, 104-113.

2021

Lan, C. B., Auclair*, K. Ammonium chloride-promoted rapid synthesis of monosubstituted ureas under microwave irradiation. Eur. J. Org. Chem. 2021, 5135-5146.
**Important paper Highlight on Chemistry Views

Kaabel, S., Therien, J. P. D., Deschenes, C. E., Duncan, D., Friscic*, T., Auclair*, K. Enzymatic depolymerization of highly crystalline polyethylene terephthalate enabled in moist-solid reaction mixtures. Proc. Nat. Acad. Sci. 2021, 118, e2026452118.
**Important paper: Highlighted by Quebec Science

Ducharme, J., Sevrioukova, I. F., Thibodeaux*, C. J., Auclair*, K. Structural dynamics of cytochrome P450 3A4 in the presence of substrates and cytochrome P450 reductase. Biochemistry, 2021, 60, 2259-2271.

Duncan, D., Lupien, A., Behr, M. A., Auclair*, K. Effect of pH on the antimicrobial activity of the macrophage metabolite itaconate. Microbiology, 2021, 167, https://doi.org/10.1099/mic.0.001050

Ducharme, J. D., Thibodeaux*, D., Auclair*, K. Combining small-molecule bioconjugation and hydrogen deuterium exchange mass spectrometry (HDX-MS) to expose allostery: the case of human cytochrome P450 3A4. ACS Chem. Biol. 2021, 16, 882-890.

Guan, J., Spry, C., Tjhin, E. T., Yang, P., Kittikool, T., Howieson, V. M., Ling, H., Starrs, L., Duncan, D., Burgio, G., Saliba*, K. J., Auclair*, K. Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides. J. Med. Chem. 2021, 64 (8), 4478-4497.

2020

Hammerer, F., Ostadjoo, S., Dietrich, K., Dumont, M.-J., Del Rio, L. F., Friscic*, T., Auclair*, K. Rapid mechanoenzymatic saccharification of lignocellulosic biomass without bulk water or chemical pre-treatment. Green Chemistry, 2020, 22, 3877-3884.

Hammerer, F., Ostadjoo, S., Friscic*, T., Auclair*, K. Towards controlling the reactivity of enzymes in mechanochemistry: inert surfaces protect β-glucosidase activity during ball milling. ChemSusChem, 2020, 13, 106-110.

Swain, A., Bambouskova, M., Kim, H., Andhey, P. S., Duncan, D., Auclair, K., Chubukov, V., Simons, D. M., Roddy, T. P., Stewart, K. M., Artyomov*, M. Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages. Nature Metabolism, 2020, 2, 594-602.

Kaabel, S., Friscic, T., Auclair*, K. Mechanoenzymatic transformations in the absence of bulk water – a more natural way of using enzymes. ChemBioChem, 2020, 21, 742-758.

2019

Ostadjoo, S., Hammerer, F., Dietrich, K., Dumont, M.-J., Friscic*, T., Auclair*, K. Efficient enzymatic hydrolysis of biomass hemicellulose in the absence of bulk water. Molecules 2019, 24, 4206.

Kaabel, S., Friscic, T., Auclair, K. Mechanoenzymatic transformations in the absence of bulk water – a more natural way of using enzymes. ChemBioChem 2019 http://dx.doi.org/10.1002/cbic.201900567.
**Invited to provide a cover art for the issue because within top 20% articles

Hammerer, F., Ostadjoo, S., Friscic*, T., Auclair*, K. Towards controlling the reactivity of enzymes in mechanochemistry: inert surfaces protect β-glucosidase activity during ball milling. ChemSusChem, 2020, 13, 106-110.

Wang, Y., Guan, J., Di Trani, J. M., Auclair, K., Mittermaier*, A. K. Inhibition and activation of kinases by reaction products: a reporter-free assay. Anal. Chem. 2019, 91, 11803-11811.

Duncan, D., Auclair*, K. The coenzyme A biosynthetic pathway: a new tool for prodrug bioactivation. Arch. Biochem. Biophys. 2019, 672, 108069-108083.

Therien, J. P. D., Hammerer, F., Friscic*, T., Auclair*, K. Mechanoenzymatic breakdown of chitinous material to N-acetylglucosamine: the benefits of a solvent-free environment. ChemSusChem 2019, 12, 3481-3490.
**Very important paper
**Invited to provide a cover art for the issue

Ducharme, J., Polic, V., Auclair*, K. A covalently attached progesterone molecule outcompetes the binding of free progesterone at an allosteric site of cytochrome P450 3A4. Bioconj. Chem. 2019, 30, 1629-1635.

2018

Guan, J., Barnard, L., Cresson, J., Hoegl, A., Chang, J. H., Strauss*, E., Auclair*, K. Probing the ligand preferences of the three types of bacterial pantothenate kinase. Bioorg. Med. Chem. 2018, 26, 5896-5902.

Guan, J., Tjhin, E. T., Howieson, V. M., Kittikool, T., Spry, C., Saliba, K. J., Auclair*, K. Structure-activity relationships of antiplasmodial pantothenamide analogs reveal a new way by which triazoles mimic amide bonds. ChemMedChem 2018, 13, 2677-2683.

Guan, J., Vong, K., Wee, K., Fakhoury, J., Dullaghan, E., Auclair*, K. Cellular studies of an aminoglycoside potentiator reveal a new inhibitor of aminoglycoside resistance. ChemBioChem 2018, 19, 2107-2113.

Polic, V., Sevriouikova, I. Auclair*, K. Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency. Arch. Biochem. Biophys. 2018, 653, 90-96.

Bambouskova, M., Lampropoulou, V., Sergushichev, A., Loginicheva, E., Johnson, K., Mathyer, M. E., Gorvel, L., Kim, H., Huang, L.-H., Duncan, D., Santeford, A., Apte, R., Jha, A. K., Johnson, B., Amarasinghe, G. K., Soares, M., Klechevsky, E., Sato, T., Hai, T., Akira, S., Virgin, S., Strong, C. de G., Auclair, K., Roddy, T., Stewart, K. M., Randolph, G., Artyomov*, M. N. Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis. Nature, 2018, 556, 501-504.
**Highlighted in Nat. Immunol. 2018, 19, 511.
**Highlighted in Nat. Rev. Immunol. 2018, 18, 360.

Tjhin, E. T., Spry, C., Sewell, A. L., Hoegl, A., Barnard, L., Sexton, A. E., Howieson, V. M., Maier, A. G., Creek, D. J., Strauss, E., Marquez, R., Auclair, K., Saliba*, K. J. Mutations in the pantothenate kinase of the malaria parasite P. falciparum confer resistance or hypersensitivity to diverse pantothenate analogues. PLOS Pathogens 2018, 14, e1006918.

Hammerer, F., Loots, L., Do, J.-L., Therien, J. P. D., Nickels, C. W., Friscic,* T., Auclair,* K. Solvent-free enzyme activity: quick, high-yielding mechano-enzymatic hydrolysis of cellulose into glucose. Angew. Chem. Intl. Ed. 2018, 57, 2621-2624.
**Highlighted in Chemistry World, 16 July 2018.
**Highlighted in Canadian Chemical News, May 2018, Vol. 70, Issue 5.
**Highlighted in the pipeline blog from Science Translational Medicine, 29 Jan 2018.

Ducharme, J., Auclair*, K. Use of Bioconjugation with Cytochrome P450 Enzymes. BBA – Proteins and Proteomics, 2018, 1866, 32-51.

2017

Polic, V., Cheong, K. J., Hammerer, F., Auclair*, K. Regioselective epoxidations by P450 3A4 using a theobromine chemical auxiliary to predictably produce N-protected β- or γ-amino epoxides. Adv. Synth. Catal. 2017, 359, 3983-3989.

Polic, V., Auclair*, K. Allosteric activation of cytochrome P450 3A4 via progesterone bioconjugation. Bioconj. Chem. 2017, 28, 885-889.

Ducharme, J., Auclair*, K. Enzymes beat chemists in the formation of unnatural bonds. ChemBioChem 2017, 18, 432-434.

Schiavini, P., Cheong, K. J., Moitessier*, N., Auclair*, K. Active site crowding of P450 3A4 as a strategy to alter its selectivity. ChemBioChem 2017, 18, 248-252.

2016

Howieson, V. M., Tran, E., Hoegl, A., Fam, H. L., Fu, J., Sivonen, K. S., Li, X. M., Auclair*, K., Saliba*, K. J. Triazole substitution of the pantetheinase-sensitive amide bond stabilizes pantothenamides and improves their antiplasmodial potency. Antimicrob. Agents Chemother. 2016, 60, 7146-7152.

Hammerer, F., Chang, J., Duncan, D., Ruis, Angel C., Auclair*, K. Small molecule restores itaconate sensitivity in Salmonella enterica: a potential new approach to treat bacterial infections. ChemBioChem, 2016, 17, 1513-1517.

Guan, J., Hachey, M., Puri, L., Howieson, V., Saliba, K. J., Auclair*, K. A cross metathesis approach to novel pantothenamides derivatives. Beilstein J. Org. Chem. 2016, 12, 963-968.

Mariaule, G., De Cesco, S., Airaghi, F., Kurian, J., Schiavini, P., Rocheleau, S., Auclair, K., Mittermaier, A., Moitessier*, N. 3-Oxo-hexahydro-1H-isoindole-4-carboxylic acid as a drug chiral bicyclic scaffold and its application to the preparation of conformationally constrained covalent and non-covalent prolyl oligopeptidase inhibitors. J. Med Chem. 2016, 59, 4221–4234.

2015

Schiavini, P., Pottel, J., Moitessier*, N., Auclair*, K. Metabolic instability of cyanothiazolidine-based prolyl oligopeptidase inhibitors: a Structural assignment challenge and potential medicinal chemistry implications. ChemMedChem 2015, 10, 1174-1183.
**featured on the back cover page of the Journal by invitation

Freiburger, L., Auclair, K., Mittermaier*, A.K. Global ITC fitting methods in studies of protein allostery. Methods. 2015, 76, 149-161.

2014

Freiburger, L., Miletti, T., Zhu, S., Baettig, O., Berghuis, A. M., Auclair, K., Mittermaier*, A.K. Substrate-dependent switching of the allosteric binding mechanism of aminoglycoside (6') acetyltransferase-Ii. Nature Chem. Biol., 2014, 10, 937-943.
**Udho Parsini Diwan Award for the best article of 2014 in the department

Polic, V., Auclair*, K. Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis. Bioorg. Med. Chem. 2014, 22, 5547-5554.
**highlighted by the editor at: Bioorg. Med. Chem. 2014, 22, 5537-5538

Hoegl, A., Darabi, H., Tran, E., Awuah, E., Kerdo, E., Saliba, K. J., Auclair*, K. Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity. Bioorg. Med. Chem. Lett. 2014, 24, 3274-3277.

Awuah, E., Ma, E., Hoegl, A., Vong, K., Habib, E., Auclair*, K. Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase. Bioorg. Med. Chem. 2014, 22, 3083-3090.

2012

Menard, A., Fabra, C., Huang, Y., Auclair*, K. Type II ligands as chemical auxiliaries to favor enzymatic transformations by P450 2E1. ChemBioChem, 2012, 13, 2527-2536.

Larsen, A. T., Lai, T., Polic, V., Auclair*, K. Dual use of a chemical auxiliary: molecularly imprinted polymers for the selective recovery of products from biocatalytic reaction mixtures. Green Chem. 2012, 14, 2206-2211.

Menard, A., Huang, Y., Karam, P., Cosa, G., Auclair*, K. Site-Specific Fluorescent Labeling and Oriented Immobilization of a Triple Mutant of CYP3A4 via C64. Bioconjug. Chem. 2012, 23, 826-836.

Vong, K., Tam, I. S., Yan, X., Auclair*, K. Inhibitors of aminoglycoside resistance activated in cells. ACS Chem. Biol. 2012, 7, 470-475.
**Vong K. is highlighted in this issue
**highlighted in Global Medical Discovery
**Udho Parsini Diwan Award for the best article of 2012 in the department

Vong, K., Auclair*, K. Understanding and overcoming aminoglycoside resistance caused by N-6’-acetyltransferase. Med. Chem. Commun. 2012, 3, 397-407.

Tewari, B. B., Beaulieu-Houle, G., Larsen, A., Auclair, K., Butler*, I. S. An overview of molecular spectroscopic studies on theobromine and related alkaloids. Appl. Spectrosc. Rev. 2012, 47, 163-179.

Freiburger, L. A., Auclair, K., Mittermaier*, A. K. Van’t Hoff global analyses of variable temperature isothermal titration calorimetry data. Thermochimica Acta 2012, 527, 148-157.

2011

Szychowski, J., Kondo, J., Zahr, O., Auclair, K., Westhof, E., Hanessian, S., Keillor*, J. W. Inhibition of aminoglycosides-deactivating enzymes APH(3′)-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues. ChemMedChem 2011, 6, 1961-1966.

Larsen, A. T., May, E. M., Auclair*, K. Predictable stereo- and chemo-selective hydroxylations with P450 3A4. J. Am. Chem. Soc. 2011, 133, 7853-7858.

Akinnusi, T. O., Vong, K., Auclair*, K. Geminal dialkyl derivatives of N-substituted pantothenamides: Synthesis and antibacterial activity. Bioorg. Med. Chem. 2011, 19, 2696-2706.

Freiburger, L. A., Baettig, O. M., Berghuis, A. M., Auclair, K., Mittermaier*, A. K. Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme.Nat. Struct. Mol. Biol. 2011,18, 288-294.

Freiburger, L. A., Mittermaier*, A. K., Auclair*, K. Collecting variable-concentration isothermal titration calorimetry datasets in order to determine binding mechanisms. J. Vis. Exp. 2011 Apr 7, 20, pii:2529, doi: 10.3791/2529 (http://www.jove.com/details.stp?id=2529).

Yan, X., Akinnusi, T. O., Larsen, A. T., Auclair*, K. Synthesis of 4‘-aminopantetheine and derivatives to probe aminoglycoside N-6‘-acetyltransferase. Org. Biomol. Chem. 2011,9, 1538-1546.

pre-2010

Freiburger, L. A., Auclair, K., Mittermaier*, A. K. Elucidating protein-binding mechanisms by variable-c ITC. ChemBioChem, 2009, 10, 2871-2873.

Gao, F., Yan, X., Vong, K., Auclair*, K. Synthesis of a phosphonate-linked aminoglycoside-CoA bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance. Chem. Eur. J. 2009, 15, 2064-2070.
**invited to provide front piece for this issue.

Zhao, J., Auclair*, K. The activity of human CYP2D6 in low water organic solvents. Biotech. Bioeng. 2009, 102, 1268-1272.

Gao, F., Yan, X., Zahr, O., Larsen, A. T., Vong, K., Auclair*, K. Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6-acetyltransferase. Bioorg. Med. Chem. Lett. 2008, 18, 5518-5522.

Kotakadi, V., Jin, Y., Hofseth, A. B., Ying, L., Cui, X., Volate, S., Chumanevich, A., Wood, P., Price, R., McNeal, A., Singh, U. P., Singh, N., Nagarkatti, M., Nagarkatti, P., Matesic, L. E., Auclair, K., Wargovich, M. J., Hofseth*, L. J. Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. Carcinogenesis 2008, 29, 1799-1806.

Magalhães, M. L. B., Vetting, M. W., Gao, F., Freiburger, L., Auclair, K., Blanchard*, J. S. Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella enterica aminoglycoside 6’-N-acetyltransferase. Biochemistry 2008, 47, 579-584.

Chefson, A., Auclair*, K. CYP3A4 activity of in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents. ChemBioChem. 2007, 8, 1189-1197.

Chefson, A., Zhao, J. Auclair*, K. Sugar-mediated lyoprotection of human CYP3A4 and CYP2D6. J. Biotechnol. 2007, 130, 436-440.

Zhao, J., Ferras, J., Auclair*, K. Activity of human P450 2D6 in biphasic solvent systems. Biotech. Bioeng. 2007, 98, 508-513.

Yan, X., Gao, F., Yotphan, S., Bakirtzian, P., Auclair*, K. The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6’-N-acetyltransferase and the role of 6’-NH2 in antibacterial activity. Bioorg. Med. Chem. 2007, 15, 2944-2951.

Chefson, A., Auclair*, K. Progress towards easier use of P450 enzymes. Mol. BioSyst. 2006, 2, 462-469.
**featured on the cover page of the Journal and highlighted in the Chemical Biology Virtual Journal

Gao, F., Yan, X., Shakya, T., Baettig, O. M., Ait-Mohand-Brunet, S., Berghuis, A. M., Wright, G. D., Auclair*, K. Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6’-N-acetyltransferases. J. Med. Chem. 2006, 49, 5273-5281.

Chefson, A., Zhao, J., Auclair*, K. Replacement of the natural cofactors by selected hydrogen peroxide donors or organic peroxides results in improved activity for CYP3A4 and CYP2D6. ChemBioChem 2006, 7, 916-919.

Gao, F., Auclair*, K. Highly efficient P(III) to P(V) rearrangement. Phosphorus, Sulfur Silicon Relat. Elem. 2006, 181, 159-164.

Gao, F., Yan, X., Baettig, O. M., Berghuis, A. M., Auclair*, K. Regio- and chemo-selective N-6’-derivatization of aminoglycosides: Bisubstrate inhibitors as probes to study aminoglycoside 6’-N-acetyltransferases. Angew. Chem. Intl. Ed. 2005, 44, 6859-6862.

Côté, C. S., Kor, C., Cohen, J., Auclair*, K. Composition and biological activity of traditional and commercial kava extracts. Biochem. Biophys. Res. Comm. 2004, 322, 147-152.

Gaudineau, C., Welbourn, S., Auclair*, K. Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract. Biochem. Biophys. Res. Comm. 2004, 318, 1072-1078.

Gaudineau, C., Auclair*, K. Inhibition of human P450 enzymes by nicotinic acid and nicotinamide. Biochem. Biophys. Res. Comm. 2004, 317, 950-956.

Li, Y., Syvitski, R. T., Auclair, K., Ortiz de Montellano*, P. R., La Mar, G. N. 1H NMR investigation of the solution structure of substrate-free human heme oxygenase: Comparison to the cyanide-inhibited, substrate-bound complex. J. Biol. Chem. 2004, 279, 10195-10205.

Li, Y., Syvitski, R. T., Auclair, K., Ortiz de Montellano*, P. R., La Mar, G. N. Solution 1H, 15N NMR spectroscopic characterization of substrate-bound, cyanide-inhibited, human heme oxygenase-1: Water occupation of the distal cavity. J. Am. Chem. Soc. 2003, 125, 13392-13403.

Auclair*, K., Moenne-Loccoz, P., Ortiz de Montellano*, P. R. Cloning and expression of a novel heme protein from the genome of Saccharomyces cerevisiae. Prot. Express. Purif. 2003, 28, 340-349.

Sorensen, J., Auclair, K., Kennedy, J., Hutchinson, C. R., Vederas*, J. C. Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes. Org. Biomol. Chem. (formerly J. Chem. Soc., Perkin 1) 2003, 1, 50-59.

Syvitski, R. T., Li, Y., Auclair, K., Ortiz de Montellano, P. R., La Mar*, G. N. 1H NMR Detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1. J. Am. Chem. Soc. 2002, 124, 14296-14297.

Auclair, K., Hu, Z., Little, D. M., Ortiz de Montellano*, P. R., Groves*, J. T. Revisiting the mechanism of P450 enzymes using the radical clocks norcarane and spiro[2,5]bicyclooctane. J. Am. Chem. Soc. 2002, 124, 6020-6027.

Li, Y., Syvitski, R. T., Auclair, K., Wilks, A., Ortiz de Montellano, P. R., La Mar*, G. N. Solution NMR characterization of an unusual distal H-bond network in the active site of the cyanide-inhibited, human heme oxygenase complex of the symmetric substrate, 2,4-dimethyldeuterohemin. J. Biol. Chem. 2002, 277, 33013-33018.

Auclair, K., Moenne-Loccoz, P., Ortiz de Montellano*, P. R. Roles of the proximal thiolate ligand of cytochrome P450CAM. J. Am. Chem. Soc. 2001, 123 4877-4885.

La Mar*, G. N., Asokan, A., Espiritu, B., Yeh, D. C., Auclair, K., Ortiz de Montellano, P. R. Solution 1H NMR of the active site of cyanide-ligated, substrate-bound human heme oxygenase: Comparison to the crystal structure of the unligated form. J. Biol. Chem. 2001, 276, 15676-15687.

Auclair, K., Vederas*, J. C. Conversion of cyclic nonaketide precursors to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus. Bioorg. Med. Chem. Lett. 2001, 11, 1527-1531.

Sutherland, A., Auclair, K., Vederas*, J. C. Recent advances in biosynthetic studies of lovastatin Curr. Opin. Drug Discov. Devel. 2001, 4, 229-236.

Auclair*, K. Book Review: Enzymes in Nonaqueous Solvents: Methods and Protocols, J. Chem. Soc., Perkin 1 2001, 17, 2104-2107.

Auclair*, K. Book Review: Enzymes in Nonaqueous Solvents: Methods and Protocols, Nat. Prod. Rep. 2001, 5, 579-582.

Auclair, K., Kennedy, J., Sutherland, A., Witter, D. J., Van den Heever, J. P., Hutchinson, C. R., Vederas*, J. C., Lovastatin nonaketide synthase (LNKS) catalyses an intramolecular Diels-Alder reaction of a substrate analog. J. Am. Chem. Soc. 2000, 122, 11519-11520.

Hutchinson, C. R., Kennedy, J., Park, C., Kendrew, S., Auclair, K., Vederas*, J. C. Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases. Anton. van Leeuwen. 2000, 78, 287-295.

Kennedy, J., Auclair, K., Kendrew, S. G., Park, C., Vederas, J. C., Hutchinson*, C. R., Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science 1999, 284, 1368-1372.

Browne*, L. M., Auclair, K., Techniques in Organic Chemistry, Part 1: VHS Videotape, J. Chem. Ed:Software 1998, 75, 383-384. (correction of authors: idem 1998 75, 658)

Browne*, L. M., Auclair, K., Techniques in Organic Chemistry, Part 2: Videotape, J. Chem. Ed:Software 1998, 75, 1055-1056.

Peer-reviewed Books and Book Chapters (supervised trainees; corresponding author*)

Auclair*, K., Polic, V. Chap 8: Use of chemical auxiliaries to control P450 enzymes for predictable oxidations at inactivated C-H bonds of substrates. In Advances in Experimental Medicine and Biology: Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450, Eds. Hrycay, E., Bandiera, S. Springer, Switzerland. 2015, pp. 209-228.

Ortiz de Montellano*, P. R., Auclair, K. Heme Oxygenase Structure and Mechanism. In Porphyrin Handbook, Eds. Kadish K., Smith, K., and Guilard, R., Academic Press, New York, Volume 12, Chapter 75, 2003, pp. 183-210.

Hutchinson, C. R., Kennedy, J., Park, C., Auclair, K., Vederas*, J. C. The Molecular Genetics of Lovastatin Biosynthesis. In Handbook of Industrial Mycology, Ed. An, Z., Marcel Dekker Inc. New York, Chap 17, 2003, pp. 479-492.

Intellectual Property

Auclair, K., Friscic, T., Kaabel, S., and Therien, D. Mechanoenzymatic degradation of polymers. PCT/CA2020/051438, filed Oct 27, 2020. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2021081633&_cid=P12-KON0HW-66445-1 Described at: https://mcgill.flintbox.com/#technologies/3e0c9c13-d2ec-4b33-8815-eb5e62882bcc

Auclair, K., Guan, J., Saliba, K., Spry, C., Tjhin, E., Howieson, V. Pantothenamide analogs and their use as antiplasmodial drug. US provisional, filed 1 Aug 2018, Application no. 62/713,244.

Hammerer, F., Auclair, K., Friscic, T., Loots, L.-A., Do, L., Nickels, C. Enzyme saccharification of a polysaccharide. US 62/465,443 filed 1 Mar 2017. PCT filed Mar 2018.

Auclair, K. and Vong, K. Compounds for Use in the Treatment of Bacterial Infection; CA 2,860,706; filed 17 Jan 2012; pending examination in Canada.

Auclair, K. and Vong, K. Compounds for Use in the Treatment of Bacterial Infection; EP 12736727.4; filed 17 Jan 2012; in examination in Europe.

Auclair, K. and Vong, K. Compounds for Use in the Treatment of Bacterial Infection; PCT/CA2012/050029; filed 17 Jan 2012; published as WO 2012/097454; International application.

Auclair, K. and Vong, K. Compounds for Use in the Treatment of Bacterial Infection; US 13/980,364; filed 17 Jan 2012; issued as US 9,127,035 in the USA.

Auclair, K., Gao, F., Yan, X. Inhibitors of aminoglycoside 6’-N-acetyltransferases, compositions and uses thereof; US 11/359,274; filed 21 Feb 2006; issued as US 7,626,005 in the USA

Media Coverage of our Work

Our publication ChemBioChem. 2020, was within the top 20% and selected to be featured on the cover page

Guillemette, M. Recycler les molecules plutot que le plastique. Quebec Science, Dec 2019, 39-43.

Maitland, P. Molecular study could lead to an alternative to antibiotics – Dr. Karine Auclair. CIHR-III e-Bulletin Nov 21, 2019 (http://www.cihr-irsc.gc.ca/e/51749.html).

Dempsey, L. A. Immunoregulatory itaconate. Research highlight. Nat. Immunol. 2018, 19, 511.

Bordon, Y. Itaconate charges down inflammation. Research highlight. Nat. Rev. Immunol. 2018, 18, 360-361.

Notman, N. Chemists use the force: Introducing mechanochemistry. Chemistry World, 16 July 2018.

Lavik, E. Celebrating female scientists, ScientistLikeMe, Everyone is a scientist blog, Oct 2018.

McDevitt, N. Audace awardees. McGill Reporter, Sept 13, 2018.

Bouthillette, J.-F. Envoyer la science dans le champ, in the show. Les Annee Lumieres, Radio Canada, May 13th, 2018 (https://ici.radio-canada.ca/premiere/emissions/les-annees-lumiere/episodes/407018/audio-fil-du-dimanche-13-mai-2018)

Lougheed, T. Chemists get physical and Rage against bulk solvents –Mechanochemistry. Canadian Chemical News, May 2018, Vol. 70, Issue 5.

Lowe, D. Down at the small surfaces. In the pipeline blog from Science Translational Medicine, 29 Jan 2018.

Corless, V. Women’s world. Canadian Chemical News, Spring 2017.

Lai, N. Women Inventors. McGill Office of Innovation Newsletter, Mar 2017.

Our article ChemMedChem 2015, 10, 1174, was featured on back cover page of the Journal.

Our article Bioorg. Med. Chem. 2014, 22, 5547, was highlighted by the editor.

The journal Global Medical Discovery highlighted our 2012 article in ACS Chem. Biol.

Our article Chem. Eur. J. 2009, 15, 2064, was highlighted with a frontispiece.

Sun, K. Features story on antibiotic resistance. McGill Tribune Nov 2007.

The Chemical Biology Virtual Journal has highlighted our publication Mol. BioSyst. 2006, 2, 462.

Our publication Mol. BioSyst. 2006, 2, 462 was featured on the cover page of the Journal.

Aiello, R. Herbal Medicines. McGill Daily 15 Jan 2006.

McDonagh, P. The Green Chemistry Revolution. McGill News Summer 2005.

Bourdon, P. Professeur-chercheur a McGill, l’Alzheimer préoccupe Karine Auclair. Le Citadin Oct 2004.

Quest for natural Diels-Alderases yields two purified enzymes. Chem. & Engineer. News Nov 2000.

Fungi’s cholesterol-lowering secret revealed. Edmonton Journal May 21, 1999.